La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Shushu - Rusts and Breaks

    This mop has a horrible design flaw. The plastic thing that keeps the mop head attached to the handle has a large lip on it that holds water.(look closely at the picture and you will see what I mean) This area of the handle rusts through and it breaks. Two mops have broken like this in one year. Until they change the design I will never buy this again. I wrote to Libman about this issue after the first one broke and there was no response. I use a mop several times a week.

  • avid reader - Christmas Barbie is one of the Prettiest Ever!

    I belong to a doll club and this doll was shown before Christmas by another member and I just loved her. I had purchased a few of the Holiday Barbies over the years, but this was by far the prettiest one (in my opinion). I waited, hoping someone would give me this doll for Christmas, but it was not to be. I was going to order her after Christmas but she was too high priced, but later Amazon had her on sale, and since I had got an Amazon gift card for Christmas I got her, and I was so happy with her!!! A truly beautiful doll!!