La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Clint - The new labels do not say 8-ply. Don't trust older reviews; the product has changed since some time around or after 2005!

    I purchased this hose on the basis of previous Gilmour Flexogen 8-ply hoses that I've owned. The older hoses easily get 5 stars; my parents have some from the 80s or 90s that are still in excellent shape and are pretty much impossible to kink unless you're actively trying. I bought myself one around 2005 that seems to be of the same quality as my parents', and I use it quite frequently. All of these older hoses had labels that prominently said "the only 8-ply." The label on the newer hose doesn't mention 8-ply anywhere, even though the product title does. The newer hose was obviously of a lower quality as well; there are plenty of other hoses out there that kink more easily, but this one was still pretty easy to kink, unlike the older ones I've used.

  • Andrew W. Snapp - Need to be developed further

    Did not work out of box. Manufacturers said it's defective. Waited 3 weeks for replacement kit. Now I'm told it will take another month. FAIL

  • Sugar Land - Excel 2010 for Dummies

    The product is as advertised. It was immediately used by a family member to quickly learn many of the Excel Basics.

  • Jo Walter - Lightweight but does not recline, breaks hard to put on

    Whilst very light you have to push hard to move the pram with a child in it. Also found that the breaks were hard to put on as the break pedals would get stuck. Wouldn't buy it again.