La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Ouiga Boards Are For Real! - Ouiga Boards Are For Real!

    Once about 8 years ago, my mom and my cousin were playing with the ouiga board. My other cousin was there in the room and he told my mom to ask it when he was going to jail. It said "tonight". He said to ask it where he will be, It said " at Chris's house". He had planned on going there that night, but changed his mind. Later they posed the same question to the board-when was he going to jail, it again said "tonight". I was on 3rd shift and went to work. I came home at lunch, and there were police officers surrounding my mom's house. Guess what. He went to jail THAT NIGHT! My mom got so scared she burned the ouiga board. I still like to play around with them though. I can't help it, it is interesting.

  • chad.w - Amazingly well-built trampoline for the money.

    I was absolutely amazed at how well made this trampoline is. Setup was pretty easy with two grown-ups (made only slightly more complicated with our extra 11, 9, and 4 year old "helpers" :) All told it took about 2 hours from start to finish and, again, that meant letting the little helpers help where they could. It may have gone slightly faster with just two grown-ups.

  • Nelly L. - Love it

    I love that lipgloss, It is really plumping (you can feel your lips burning a little which is perfectly normal for a plumping gloss), I just thought the color would be a little bit stronger, it is really sheer