La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    I have been dying my hair for about 14 years. Naturally I have medium/dark brown hair and I dye it various shades of browns for years now to give my hair some good color instead of being such a plain brown. Anyway I recently got the bright idea to dye it BLACK. It looked decent but I could not get used to it and just felt so ugly. It was much too bold for my taste. I look best with red and gold tones in my hair. After about 3 days of being miserable with it and getting a few negative reactions I started searching for a way to change it, figuring that I'd have to live with it for months to come. Came across color oops and went to Walgreens immediately and bought 2 boxes (I have medium thick hair past my boobs). I figured at $9.99 per box it would be very worth it. I followed all directions, rinsed my hair profusely (about 25 minutes but with my long thick hair I probably should have rinsed more), washed twice followed by rinsing, then conditioned it and was pretty amazed that my hair was magically back to the color it was before I dyed it black!! Actually I think it was a bit lighter, but it has continued to darken into a nice rich dark brown with a nice red tone and some gold highlights. I actually really love it. It's the color I usually aim for when I dye it.... Anyway, it works!! Follow directions and I don't see any reason why it wouldn't work.

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