La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    I fear this is a much more dangerous product than people realize. After 4 days of two pills two times per day, as recommended, I was in pain. Not just the gastrointestinal stuff that others have mentioned, I also had horrendous pain in my upper legs and knees. Pain to the point that I was in tears. Originally I took the product for pain in my hip where I am arthritic. After going on line and reading the reviews posted here, I decided not to take Move Free anymore. Lo and behold, the leg pain was gone in 24 hours, as quickly as it appeared. I even tried to research this product on line before I bought it, but evidently missed these reviews. I couldn't find a lot of feedback. This is defintely a buyer beware.

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