La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Mickey D. Hadick - A minor, multi-colored miracle

    I read about sugru on lifehacker, and what I noticed was its use in repairing a dishwasher rack (how's about that for first-world problems?!). The cost of replacing the rack is a ridiculous $160 (thanks for that, Kenmore) so I tried this. Sugru works great, and is kind of fun.

  • Hinesy82 - Works great, used for short period of time

    This worked great. With that being said I don't recommend it. Even with regular daily use its not recommended to use during running so the avid runner should be aware of this. I have used it running and was cautious about my infants head but I didn't do it nearly as often as I would have wanted. I only actually used this for a few months and now I don't have any snack tray for either child. Recommend skipping this!

  • Douglas E. Graves - Keepin' it simple and basic

    I had what turned out to be toe fungus on my left big toe. I had lost the nail three or four times over a period of a few years. Each new nail would eventually "blister" at the base then crack and spit and loosen to the point of falling off. I finally did some web research and found some "hi-end" fancy named fungus treatments, all quite expensive. What I noticed is that they kept touting that they had "tree tea oil" in them. So I mused, this seems to be the magic curing ingredient these fancy treatments were depending on. I wondered if this tree tea oil was available on it own. Seems to me that this "tree tea oil" is the stuff I really need. Sure enough, it was available, and for a fraction of the price of the fancy names that "included" it. I ordered bottle and treated my toe diligently EVERY morning with the oil, applying it with a Q-tip for about two months, and it is now completely cured with a strong clear normal new nail. And I only used about 1/6 of the bottle to boot! My thoughts are, just use this inexpensive oil, with the key being; treating it consistently on a daily basis until one's nail grows back in normally and healthy again. :)

  • jomama4545 - bike seem to be good but it came with 2 missing parts and a ...

    bike seem to be good but it came with 2 missing parts and a bent bolt. I am now waiting for the replacement parts

  • Erich Ball - A Fun Holiday Read

    This was a good light read and I will happily buy subsequent books in the series. It's a sword and sorcery fantasy with a couple of twists. The protagonist is a young woman and there is magic in tattoos. That last one is quite topical I suppose.