La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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I love this little headlamp. It is very compact and can be worn for hours without even being noticed. The single AA battery was a huge selling point for me as it cuts down on weight and size and this lamp still last such a long time. This lamp has direct beam and flood with high/low/strobe in each. I can't imagine needing anything else in a lamp. My kids love to use it and because it so small and lightweight it fits them well. Because it last 50+ hours on the mode I prefer I don't mind them using it as it isn't going to run out of battery in the few hours they are playing with it. Great lamp, and the cool little carrying case is much more than I expected. Quality ripstop nylon with a small zipper pouch inside to carry spare batteries. Very cool product that exceeded my expectations and did not cost a fortune. Well done, would definitely buy more of these little lamps.
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