La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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I mostly bought the Wilson for the humor of it but also figured it would be decent quality. It is funny but mine wont stay inflated for very long.
Speck makes excellent cases for iphones! I had one for my iphone 4 and now did not hesitate to get one for my iphone 5. Great protection for my rather pricey toy without the bulk of the otterboxes. This color looks great especially with the white iphone!
I always am ready for a great read from Griffin and this does not disappoint at all. The problem that I have is that when I pick a new book like this I have a hard time putting it down,and this proved to be no exception, rats! Now have to wait to see what happens next. Another cliff hanger,
As usual, Steves pulls no punches, and let's you know exactly what he thinks-good and bad. This is usually helpful, but sometimes means some areas get shortchanged. I know he isn't a fan of Malaga, but at least give us the town's pronunciation! Other than that, his thorough explanations, invaluable tips and fun prose make this my go to travel author always. Thank you!