La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Amazon Customer - Fantastic planner!

    Wonderful planner! Has enough space to write appointments, tasks, etc. without being a huge planner. Also love the monthly view and all of the tabs!

  • Michelle - Disappointed

    I bought Just Dance 2015 because we loved Just Dance 3, and this song list looked like it had potential to be just as fun for my whole family. Unfortunately, we were pretty disappointed. There are a few fun dances, but most are more like music videos for entertainment rather than encouraging actual dancing. Also, the navigation is sticky and the wait time for different aspects to load is long. I will give this game a few more tries, but overall, this was not worth the money.

  • Emily V - It's great

    This is just a quality blender that I love. I purchased it because consumer reports gave it a high rating so I went with what they had to say. What I like about it is that it is very sturdy and solid when blending. The blade on this is SERIOUS! (which I love). It is all dish washer friendly and I've been enjoying it very much. I like how it doesn't give me 4,000 useless options and just has it simplified to what my needs are. My boyfriend and I like to make shakes and iced coffee, so our experience with the blender is largely from that.

  • toutdemoi - Good Deal!

    I just started reading the book today and I found it pretty useful. I bought an old one for $24 that gave me access to both the book and the online program. The only problem is that it doesn't contain the tear-out study guide that I really wanted. :( So I'm giving it a 4 star.