La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • dobo97 - Going back to Miracle

    I have been satisfied with other Philosophy products and had high expectations for this moisturizer but I've been really disappointed. The smell is super strong so much so that last night my eyes watered for 10 minutes after using it. It does not blend in well - in some areas it seems to sit on top of my skin while others it soaks in appropriately. "Miracle" product is so much better and felt luxurious - this feels likes whipped margarine. An expensive mistake I will not make again.

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    I bought this product about a year ago and finally got to apply it. There was no mention of a hose to load the mixture into the sprayhead so I had to use a soda straw cut on a bias, applied to the small inlet boss on the underside of the spray head.. The seed would settle out on the bottom and there was insufficient suction to draw it into the spray head within a minute. This is a product that has a promising concept which it, unfortunately, doesn't fulfill.

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    Upon installing this on my wife's computer, I found that some websites do not work well with Internet Explorer that worked fine with our previous AV, Kaspersky. Some of them refused to respond at all and Norton gave me no notice of what to do about it. After consulting with fellow computer nerds, I switched her browser to Firefox and was able to make everything work as before.