La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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Country: 83.140.155.4, Europe, SE
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I took a PMP prep class through my job and this was the reference provided by the instructor's company. I read it cover to cover during the two-week course (in accordance with the syllabus) and listened to the entire CD collection during the course. I used the CDs as a supplement driving to and from work during the course dates. Also listed a second time in the days leading up to the PMP exam. Now the question everyone actually cares about with these reviews. Did I pass the PMP? Yes, on my first attempt. I used this specific Andy Crowe material along with a text by Furman in order to get a second take on PMI's material. The online test bank was very helpful in that it gave insight into how PMI crafts questions and how you need to wrap your mind around the material.
Works flawlessly, and 100% necessary if you want to take your tot on walks before she is old enough to sit in the BOB itself (outside of the Graco seat). Highly recommended.