La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Brian D Westfall - Pay for ever

    I have been using photoshop for years. The original price was steep but since older versions work fine for my needs, I have no reason to upgrade. I have only done so a couple of times over the past decade. Well, Adobe just assured that I will never upgrade again because they want to charge you forever. Great deal for them, not for the customer.

  • Ignite - A very good read

    Sophie has just gone back to work, in the publishing industry, after her daughter started school. It’s her dream job in a children’s book publishing company. At university she discovered her friend Jasmine was the grand-daughter of the company director. Unusually, she hated her grandfather. In the story, we go back and forth between the present day and their time at university.