La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Alan B. Cring - Do not use this software

    Yeah, last year, tax year 2012, I filed for my corporation with this trash. I filled out Form 2553 to elect S Corp status. After I filed electronically, the print-out of my forms showed the Form 2553 along with all the other documents. Turns out, TurboTax for Business doesn't file that form electronically. No warning. It just didn't file it. Now, for tax year 2013, the IRS does not recognize my company as an S Corp, and I'm in hot water. I bought that "audit defense" product, and I can't even find a way to use it. I called the number that was in the receipt for it, and some totally clueless young woman told me she didn't have any information about the product, but she'd give me a Website link via e-mail. That turned out to be a dead link. I finally found a Website from TurboTax to the audit defense site, but all I could find there was a phone number back to the same place where I'd talk to Rocket Science Girl. There was also an e-mail link, and when I sent a message to that e-mail address, it got returned to me. If I had the money, I'd sue TurboTax. If I had a government with a real consumer protection agency, I'd file a complaint in a heartbeat.

  • Excellent. Easy to read. Much helpful information. - Excellent. Easy to read. Much helpful information.

    Mr. Landis has succeeded in making a very complicated subject comprehensible to the average reader. All my questions about how the system works were answered. I appreciated the fact that Mr. Landis was employed by the Social Security Administration for many years and was able to give an insider's account of procedures and benefits. Many thanks for this very helpful book!