La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Dr. Kellyann Petrucci | Nutritionist, Author & Paleo Food & Lifestyle Expert - Author of the following books from Wiley Publishing: Living Paleo for Dummies, Boosting Your Immunity for Dummies, Paleo Cookbook for Dummies and many more.

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  • Karena Lynn - Great clock

    Love this! After eading the instructions it was simple to set the clock and alarm and preset all the radio stations!

  • peonies12 - We use this daily, no problem

    Fits waterbottles, keys, cell phone, pack of gum... we also use one pocket to stuff the mosquito net into, no problems at all. Is sturdy and stays on even with all the baggage.