La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    Suddenly my skin started to sag, and look wrinkly - causing my skin to look much older. Instead of looking like 29 year old skin, it started to look like 80 year old skin. I read about this product, and decided to give it a try. Some of the reviews complained about the scent - I just add vanilla scented lotion, and it covers the scent nicely. I am sooo glad that I ordered this. I have been using it for about 3 weeks, and there is a definite improvement, since there is way less sagging - looks like a 50% improvement. Definitely a great product.

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  • hubble15 - Very well engineered

    We chose this stroller after researching & test-driving everything we could get our hands on. My wife took a liking to it immediately, and each stroller we tried after the Uppa just made her like it more. Our baby is 2 mos old now, so we've had time to live with it for a while, and we have no regrets! Some observations: it is very stable; the center of gravity is low enough and the wheels are wide enough that I don't worry at all about it tipping over. Contrast that w/ Stokke, which makes me cringe just looking at it. The bassinet is great (we haven't used the seat yet), and the adapter for our car seat works like a champ. Folding & unfolding are a snap once you figure out the trick. Very fluid: fold in 2 motions, unfold in one. It is a big stroller ... we'll buy a smaller one for air travel ... but it's engineered so well in so many ways. An example: the geometry b/t the handle & rear wheels is perfect; to go down stairs you apply a bit of pressure to the handle to lift the front wheels and then ease it down the stairs on the real wheels very smoothly. It drives straight & smooth, and turns on a dime. Overall, we're very happy with it, especially considering it comes w/ so many extras.