La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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I really do not understand the sub five star let alone the 1 star reviews. This is a great book. A lot of time and research was done to find what separates the good from the great companies. I can only assume that sub 5 star reviewers own businesses that are doing doing that great or are not in business at all...anymore.
I started using this about a year ago. At first I was hesitant to purchase it because of the price, originally saw it at Ulta for about twice as much and then found on Amazon for a decent price, or at least decent enough to give it a try. I must say, I loved this from the get go. You can immediately tell that this is a quality product by rubbing the cream in your fingers. There is no oily residue whatsoever and as soon as you apply it to your face, I swear it starts glowing. I also like that you don't have to use a lot at all, 1 pump every evening does the trick. After using this for a year now, I have noticed a huge difference in my skins complexion and feel. I used to get dry patches around my mouth and chin, those are gone. I had a super oily T zone, that has been reduced significantly. I have a lot of scaring from when I was younger and had bad acne, now because of my complexion and tone, I barely wear any makeup. I also used their Performance Peel (1 box/period) which also made a huge difference in the reduction of my noticeable scars (anyway that's another product that I need to review, lol). The pump is awesome and actually gets every last drop in the bottle (I tore it apart to make sure, lol). This is a great cream and I would recommend to anyone looking for a boost to more natural, healthy skin!