La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • C. Robinson - The perfect sequel to Atlas Shrugged

    Ayn Rand's The Fountainhead starts with the words, "Howard Roark laughed." Her Atlas Shrugged began with "Who is John Galt?" This, Rand's long lost novel, begins with the auspicious "10097". From this, she quickly moves into her main point: the struggle of evens versus odds, primes versus non-primes, light against darkness, and most importantly A versus non-A. As you read this book, you will find yourself immersed in a realm of pure abstraction, as you witness the struggle of the good (which I suspect are the evens, but maybe I'm wrong) against evil. You will watch the "prime" movers change the course of destiny. If you loved when Howard Roark was on the elevator of his building with Dominique in the Fountainhead; if you loved when John Galt made the sign of the dollar in Atlas Shrugged, then you will love when . . . no, I can't ruin this for you. Bravo Rand.

  • Aaron - good game

    very fun game and cool graphics and also very very very very very addictive guns are awesome way better then hunter reloaded