La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    This binder is decent, but I would prefer it to include the black plastic thing on the inside so that I can flip the women back to the front when they get out of line. That said, it adequately holds all of the women and they don't usually get stuck on the rings inside. Although, when I pile my binders full of women on top of each other, the weight causes the rings to buckle a little bit and misalign and then sometimes my women do get caught on the rings. But we all know how women are, right? Typically heavy and hung up on rings! So as much as you may be tempted to pile and lay your binders of women on their sides, women end up being much more useful when upright.