La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • John Tilelli MD - Good idea, nice implementation. One killer problem.

    Bought this with high hopes. Setup was pretty easy. Range is kinda short, like, If you left your keys in the bedroom you probably could find them from the living room. Gives you a warning if you are getting out of range. Here's the problem and its a killer. The battery only lasts for 2 or 3 days. I got my pack with a spare battery and it ran out like overnight, so I installed the spare and it ran out in 2 days. I bought some a pack of spares thinking that maybe the batteries in the pack were old. Nope, died in 3 days. The form is nice, the software is pretty good, but the problems with battery life are a deal-breaker.

  • SNY531 - Good

    I got this stroller instead of an umbrella stroller, to travel with and keep in the car. It's not the lightest although is definitely lighter than my Uppababy Vista.