La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Lee S - It's been like a gift from the gods---didn't work fast but when ...

    I have a small Maltese mix--tried everything, have always had dogs, never had any problems--used drops, collars, whatever was popular--always took care of fleas..But this year has been different--very different. Just could not find anything that succeeded in keeping her flea free. (My cupboard is a sight to behold--contains every anti flea product known to man--sprays, powders, shampoos, collars, drops---I mean I covered the market). Was at my whits end--finally vet suggested this collar. It's been like a gift from the gods---didn't work fast but when the active ingredients kicked in it was absolute. That was about two years ago---Am on her third flea collar now and she has remained flea free ever since. Beyond that vet said suppose to be better for pets than some products. If other products still working for you---stay with them--But if they no longer seem effective this is what you need.

  • Nicole Finley - Smoke but no fire

    It doesn't get the hair close to bone straight. You can get better results using a bliw dryer that has the comb attachment on it. Update 9/7/16 so the company reaches out to me and state the are going to send an replacement item if I give a higher review...90 days later I have not herd heard from them if it was possible I wouldn't govevany stars.

  • sue hermanson - Poor Quality

    Wouldn't turn on for more than 2 sec after charging all night. The way it sits in the charger makes it easy to knock over. Don't waste your money.

  • Amazon Customer - Good shoe just wrong size.

    Ordered a size 40 got a 44 instead. Sent the shoes back Thursday (sept 15th 2016). Looking forward to the right size.