La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Gastroenterology Diagnostic Center :: Tomball Gastroenterologists|Dr. Shabbir Jamali, MD|Gastroenterologists in Houston - Dr. Shabbir Jamali completed his Internal Medicine Residency at Wayne State University Medical Center in Detroit, Michigan. There he received the award for “Best Intern of the Year” for his performance. He then completed his Gastroenterology Fellowship at the University of Connecticut. Dr. Shabbir Jamali. is Board Certified in Gastroenterology and Internal Medicine by the American Board of Internal Medicine(ABIM). Dr. Jamali is a member of the American College of Gastroenterology(ACG), American Society of Gastrointestinal Endoscopy(ASGE), Texas Society of Gastrointestinal Endoscopy(TSGE), Texas Gulf Coast Gastrointestinal Society, Texas Medical Association(TMA), and the Harris County Medical Society(HCMS).

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