La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Margaret Lorimor - A pillar switches fit good and molded to the body as described

    A pillar switches fit good and molded to the body as described..I bough rough country and had to send it back as it didnt fit to the body

  • robert - welll it meet my expection!!

    welll it was nice and easy install i didnt like on how long it took to get here a month really but dont get me wrong after setting it up it amazed me on what all you can do out it

  • Roman - Best car seat ever

    Best car seat ever. Easy to wipe clean. My son hated his infant car seat and always cried. Now he loves being in this. He can see out the window. We will be rear facing for a long time. Also, Clek customer service is the best. I was unsure it would fit in the back of my mom's VW Beetle. I contacted Julie at Clek and she went to a dealership to test it out. She went above and beyond. I will for sure buy Clek for now on.

  • ToolNut102 - Dangerous - creates false sense of security

    Unknown as to how effective this product is at virus detection/prevention/cleanup. It is useless against adware and many forms of malware. Browser hijacks, etc. from adware are considered acceptable (per Webroot tech support), so they don't search for or remove these infections. Several malware fragments were not found by Webroot, whereas other products were at least able to find the malware.