La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Aeson - my red wine keeps pretty well under vacuum for about a week

    I've had this vacuum pump for several years, and the pump and stoppers still work well being used about once a week. It definitely makes wine keep much longer than it would without the vacuum. In a refrigerator that's in the 34-40 degree range, my red wine keeps pretty well under vacuum for about a week. I've kept wine for two weeks, and it is not as good, but drinkable.

  • MR.Spazzington - Records clear audio great for spying AND recording lectures in class!

    Upon opening the package everything was in order, everything was included. Reading the reviews before purchasing rendered me a bit iffy because a lot of them say to be very still while recording but that can look SUPER obvious, I don't need to spy on anyone but I used it to record my class session, I asked my professor if it was okay to record the lecture and he said fine! I was sitting in a big lecture hall, about in the middle, over 200 students in the class, and I was able to hear the recording perfectly, I was writing notes with the pen so the speaker was always up and on the right side. The USB cable connected to my laptop and I got the sound file easily using Windows 10. Haven't used the video feature to record anything yet but I toyed with it and it's pretty clear, but like I mentioned earlier best to be still with it, being a pen it will shake a lot!