La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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Helped me understand some of the things in Excel, but had to read a lot to find specific things that I needed. Had to rely on a few friends to help me through some things that I couldn't find in the book. It also had many things that were very basic and I didn't need to know the very basic things about Excel. All in all a good start to learning Excel, but working with the program and trying different things was the best learning for me.
As usual, Bella Forrest wrote an excellent book. I really enjoyed this book, it was well written, well edited and was an all around great story. My only issue with this book is the same I've had with previous books, the use of 'with bated breath'. I don't know why that phrase bother me so much, possibly because she uses it in every book at least once, often times more. Not exactly a glaring fault, just my personal opinion