La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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I have not gotten yet. This will be a gift for young lady and it is adorable. A present like this is sure to bring a smile. I cannot wait to see. I also bought a little wallet to go with, and put some coin and paper money in it of course, being a Christmas present. Loretta
Very nice and affordable wireless/bluetooth earbuds. I discovered that these have a handy magnet at the outside, flat end of each earbud which allows them to "stick" together around your neck when you don't have them in - maybe I won't lose them this time! One note about the fit - the little contraptions for these (or any other brand/make of earbud) that are supposed to help keep them in your ear actually don't work so well for me - small ears I guess. These things actually reduce the bass significantly. So, I took those off and tried the larger size ear pieces and bang!, problem solved and the bass sounds great and they stay in fine when I'm running. They went from 3 star sound to 5 star. May not work for everyone, but good luck!