La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

CTSI Launchpad at UCSF - Turn Your Research Findings Into Patient Benefit. Launchpad brings you ideas, tools and examples to help.

  • http://launchpad.ucsf.edu/about-launchpad/ About LaunchPad - Launchpad - UCSF CTSI Launchpad project stemmed from our experience with the Catalyst Awards Program
  • http://launchpad.ucsf.edu/portfolio-item/retinal-imaging-to-screen-for-neurological-diseases/ Unmet Need in Screening for Neurological Diseases - Launchpad - The non-invasive retinal imaging innovation may help guide current treatment and support the development of new therapies.
  • http://launchpad.ucsf.edu/portfolio-item/ocular-implant-to-improve-quality-of-life-and-clinical-care/ Addressing Unmet Needs in Treating Ophthalmic Diseases - Launchpad - Drs. Desai and Bhisitkul recognized that their novel ocular implant addresses a critical unmet need for patients and clinicians.
  • http://launchpad.ucsf.edu/portfolio-item/a-target-product-profile-based-on-patient-and-provider-needs/ The Target Product Profile for An Artificial Kidney - Launchpad - Dr. Roy recognized the unmet needs for people undergoing dialysis and is developing a better solution by first addressing the target product profile..
  • http://launchpad.ucsf.edu/portfolio-item/part-1-identify-commercial-partner-2/ Part 1: How to Identify an Industry Partner - Launchpad - identifying industry partners, building relationships with sales representatives, business contacts
  • http://launchpad.ucsf.edu/portfolio-item/part-2-ask-potential-commercial-partner-2/ Part 2: Key Questions You Should Ask an Industry Partner - Launchpad - Industry partners, development of intellectual property, commercialization, sales, marketing and distribution
  • http://launchpad.ucsf.edu/portfolio-item/clinician-researcher-gets-expert-advice-for-her-novel-cancer-therapy/ Promising Early Research Gets Support to Demonstrate Value - Launchpad - Researchers developing recombinant fusion proteins that activate death receptors to kill cancer cells.

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  • ChilinMichael - Clean, well built fast wireless charger

    I have used this charger for part of the day with my S7 Edge and I'm thoroughly impressed. It's much faster than normal wireless charging. Luckily the look of this charger even matches my current Caseology case so that's a bonus. Compared to the official Samsung charger it's a fraction of the cost and does the same. Would highly recommend.

  • sheema - Great ending Ms.John!!

    This story was so good and the perfect ending to this series. Ramsey is bad with his crazy butt...he actually takes crazy to a new level lol. Straight banger!