La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Silva NYC - I love this stroller so far

    I love this stroller so far, it's lightweight and easy to get around with. I had at first some trouble with it being difficult to close, but then I quickly realized it was because the shad had slid down the frame and the part where it was attached was preventing the frame from folding completely (and therefor not latching). The fix was as simple as being aware to pull the shade up the frame before closing up the stroller.

  • parkyoojin - works well

    This Vitamin C Facial Cleanser is nice, it doesn't leave my skin crazy dry or unclean. I like the slight citrus scent that it has. My routine is to wash, then use a micellar toner, then a vitamin C serum, then some egyptian magic cream for my eyes, and then my high spf moisturizer. This facial cleanser is only 4 ounces, so it doesn't seem like a lot and I'm not sure how long it'll last. I only use one pump in the morning and one at night. I think that's the only downside to this, is that it's just not going to last very long and if I end up really really liking it, I'll probably have to refill my order every couple of months. Anyway, I still like it and have had my friend and sister try it out and they've liked it as well and none of us have had any poor or allergic reactions to this.