La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

3rd National AIDS Conference Malaysia | 3rd National AIDS Conference Malaysia, 11-12 October, MS Garden, Kuantan, Pahang, Malaysia. - 3rd National AIDS Conference 2014 ARV GUIDELINES IS CURRENTLY AVAILABLE IN PDF ARV_Guideline2014  (PDF Version)   About the conference Much has changed since the 1st National AIDS Conference (NAC) was held in Kuala Lumpur in 2007. Prevailing political and economic orthodoxies have given way in the wake of the economic crisis – compelling all parties…

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