La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Andy Leviss - This is THE recording of JSC

    I've watched/listened to the movie, seen the recent Broadway revival, and I have to keep coming back to this recording as the best, bar none. Steve Balsamo is amazing as Jesus -- his falsetto is incredible (I'm not a vocalist myself, but I have friends who are training in classical music who literally dropped their jaws when they heard Balsamo's "Gethesemane"). His power over the role drives you to tears at moments, as does Zubin Varla's terriffic Judas -- the "cracking" another reviewer mentioned wasn't his voice slipping, it's his characterization -- he's feeling pain, feeling death, and unsure -- and you feel every moment of it. Joanna Ampil is pretty good as Mary (although I think she was better in "The Complete Miss Saigon" as Kim), Alice Cooper brings a brilliantly different twist to King Herod, and the rest of the cast is terriffic.

  • IWAU - Disappointed

    I ordered the Quicken Home & Business 2010 thinking it was the manual but it turned out to be the software. It was not boxed and was in a CD cover only. I returned it right away because that was not what I needed and I didn't get a full refund.