La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Terry - Great knife but the sheath hardware corrodes in saltwater

    I am writing this review after six-months of use. The reason for the missing star is due to the sheath having a knife-locking system made from a softer, metal that corrodes in saltwater. I love the knife and feel the knife alone is worth the price. It has everything I could want in a kayak-knife: Square semi-sharp tip, serrated edge, and most important, a recessed line-cutter on the back of the blade that will accept larger diameter cordages. The blade is nicely designed and has adequate heft that feels good in the hand, for a less-expensive, yet not cheaply made knife. While I have never drawn the knife for the use it was intended for, I have needed it for cutting cord and light prying. Now on to the sheath...finger-clasps that release the knife are made of some mild-metal and corrode badly in saltwater, even though I rinse everything I use in fresh water within an hour of getting home. I'm guessing I will need to discontinue using the sheath after a year because the corrosion will be advance enough to effect the integrity of the sheath. Had the option been available, I would have paid more for this knife with stainless steel hardware.

  • Maegan - This case also has a cover to go over the charging port which is a nice feature. Ultimately this case protects the Iphone 7 ...

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