La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Alcohol and American Life - Proof Blog - The New York Times - The New York Times's Proof blog looks at the role of alcohol in American society — drinking culture and celebrations, alcoholism and its treatment.

  • http://proof.blogs.nytimes.com/2009/04/13/last-call-readers-speak/#respond Last Call: Readers Speak - The New York Times - A sampling of some of the insightful and colorful commentary from readers of Proof.
  • http://proof.blogs.nytimes.com/2009/02/12/country-vodka-and-sour-cream/ Country, Vodka and Sour Cream - The New York Times - An emigre from St. Petersburg in search of authentic Russian drinking finds himself in the cafes of Brighton Beach, where vodka and food are inseparable.
  • http://proof.blogs.nytimes.com/2009/01/30/the-tipsy-hero/ The Tipsy Hero - The New York Times - There is plenty to learn from the ancient Greeks, for whom drinking wine was a near-sacred activity.
  • http://proof.blogs.nytimes.com/2009/01/21/pencils-down-bottoms-up/ Pencils Down, Bottoms Up - The New York Times - For one English teacher, the ritual of after-school visits to the bar feels slightly illicit, and absolutely essential.
  • http://proof.blogs.nytimes.com/2009/04/03/my-fantasy-relapse/#respond My Fantasy Relapse - The New York Times - Sober or not, some things — like impending nuclear disaster and come-ons from Hunter S. Thompson — clearly call for a drink.
  • http://proof.blogs.nytimes.com/2009/03/30/time-and-the-bottle/#respond Time and the Bottle - The New York Times - Considering the merits of a “wasted” youth, from the far side of 40.
  • http://proof.blogs.nytimes.com/2009/03/22/your-signature-cocktail/#respond Your Signature Cocktail - The New York Times - Does the choice of drink say something about the drinker? And if so, what is the meaning of a strawberry daiquiri?
  • http://proof.blogs.nytimes.com/2009/03/13/the-pursuit-and-pleasures-of-the-pure-spirit/#respond The Pursuit and Pleasures of the Pure Spirit - The New York Times - A producer of artisanal eau de vie in Oregon faces hurdles, but reaps rewards — like the right formula for making a liquor from the essence of Douglas Fir trees.
  • http://proof.blogs.nytimes.com/2009/03/10/dry-run/#respond Dry Run - The New York Times - Without the option of drinking to pass the time, there was only one reasonable thing to do: run the Marine Corps Marathon.
  • http://proof.blogs.nytimes.com/2009/02/27/a-perfect-pear/#respond A Perfect Pear - The New York Times - The founder of a distillery in Oregon on how his life in local agriculture shaped his approach to making spirits.

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  • Amazon Customer - Authentic

    I love watching Chip and JoJo on Fixer Upper. I have been a fan since I caught an episode mid first season. This book gives some insight into their lives that explains why we all love them so much. They are the real deal, everything's not perfect, God and family loving couple. I am happy for their success and all the ways they can reach people.

  • Ryan and Heather Vidal - Feel great but don't last

    I bought these boots for a three day hiking trip. I wore them a few times to break them in first as you should any boot. They fit great and feel good. The reason for the one star is after only a few trips out the sole on one the shoes is starting to separate from the boot. I would expect this after somewhat extended use but not after roughly 30 miles of hiking. I will probably just super glue it back on but won't be trusting these for any extended uses again.

  • Michalla Wainwright - Could be A LOT better

    This book had so many errors in it! It's awful! From grammatical errors, to giving the wrong answers & formulas! I bought this book so I had something to study with to HELP me! & I second guess all the answers & tips because of all the things that I have found wrong in the book. I wouldn't recommend this version to anyone & I pray & hope I still pass my test. & if I do... It won't be because of this book.