La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Faolin's mom - Best car seat ever.

    This is the best purchase for extended rear facing. My two year old has her legs almost straight when she sits in this seat. A huge improvement over the Britax and Diono where her knees were squashed and in her face. It is very heavy and solid. The listing said 2014 but the seat I received was made in 2015. Very happy with this seat and I would not hesitate to buy it again.

  • Mikhail O. - Great looking bike

    Great looking bike, received it within a week. Im not sure why people complain about the wobbly wheels, mine came out fine. Must have gotten lucky. Tires were a bit funky, so I replaced them with continental gator shells. Bike is fast, rides smooth and, shifts well. Its a pretty sexy looking bike too, I had to wait for my faghettaboutit mini ubolt to get here before I could lock it up. Im a newbie, and if you are too get this bike youll treasure it. At least until you run it into the ground like I plan to.