La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Research Integrity and Peer Review | Home - <p><i>Research Integrity and Peer Review</i> is an international, open access, peer reviewed journal that encompasses all aspects of integrity in research publication, including peer review, study reporting, and research and publication ethics. Particular consideration is given to submissions that address current controversies and limitations in the field and offer potential solutions.</p>

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  • R. Larson - Good Quality and Reliability for Sewing Heavier Materials

    I've used this HD Singer for about six months on a monthly basis and have been very satisfied with its quality and reliabilty. I like the fact I can sew heavier materials (jeans, some canvas, regular cloth materials) using the right needle and thread and its easy to use settings for different types of stitches and reversible motion works very nicely. I used an older Singer pro model for creating canvas type products several years ago and this one would almost do the same, but I suspect really isn't built for it long term. The plastic housing seems durable enough and should last for many years. However, keeping it well maintained may surprise me. Comes with a button holer and many other accessories. I purchased metal bobbins and heavier needles to complement this machine, which all work well. The foot control seems cheaply made of plastic, but has worked well so far.

  • L. Lynch - Highly recommended card program!

    Pretty nice card program, I did prefer the older version. It is easy to use, but I would have liked more sentiments for cards. I did think the older program had better graphics This is one of the best ones available now

  • Donna Jones - IMPRESSIVE!

    I'm so glad Supersmile actually does what it says it does. I bought this product for periodic use because I drink coffee, tea, and cola. I was convinced after about 2 weeks of using it, when I noticed my teeth were shades whiter than before. The product isn't what sold me. The results did...