La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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This book is about a sassy, mouthy shifter named Jessa. I loved this book it is one of my favorites. Reasons why I loved it are: Jessa is not thrown into a world she didn't know about, she is strong physically and emotionally, she has a great circle of loyal friends/family (her pack), there is no "romance" and s*** hits the fan, so lots of little twists. There is a love interest or two but this is not the main focus of the story, great set up for the trilogy. Original plot and great characters and I love the eye candy in the book. Just read it.
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