La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Kindle Customer - Well worth the wait!!

    Loved this story from beginning to end. Loved their love, even cried at the end. Can't wait for the next one!!

  • Mom2Many - Almost great.

    We searched long and hard before deciding on this bike as a gift for our 16 year old son. We were all hopeful that the nearly $300 price tag would provide the same quality. The bike arrived and right off my son was thrilled. So thrilled he was okay with the broken reflector and missing break cord. We were less pleased but glad he was happy. We have searched the packaging thoroughly (and repeatedly). The break cord was not included. Kind of a big deal for a bike.

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