La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • J. McElliott - jury's still out

    it's a nifty little self contained seat, which is what I like. The attached bag for travel is a great design feature as is the nice little pocket at the back of the chair. The clips that secure the child are a bit hard to get to when our little guys is in it (and wiggling around trying his best to subvert your attempts at locking him down.) We also have the Fisher Price Booster that we use at home, and it's much easier to clip him into that chair than this one.

  • Horse Lady - ... used it three times and apparently the battery is bad now. I charge it

    I've used it three times and apparently the battery is bad now. I charge it, the tool works for a few seconds then quits. I should have gone with the Dewalt but didn't want to spend the money. Now I will spend it on replacing batteries instead. Live and learn.