La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Amy Browning - Nice machine for home use.

    Very good machine. My husband and I love it. He set it up himself by watching a YouTube video. Very heavy. The speakers are great for hooking into an iPhone or iPad. Has a fan that is very nice for cooling. The belt moves smoothly. I walk at about 3 mph and my husband runs at 5.5 mph. It works very well.

  • Margaret Smith - A SPARKLING WHITE SMILE

    Okay, mea culpa ... I smoke -- but only occasionally and only outside, so few except close friends know about my socially unacceptable habit. I use the Supersmile Whitening System to keep my teeth stain-free. It works like a champ, even on aging, previously yellowing teeth like mine. Once I had achieved a state of toothsome whiteness, I stopped using the product twice daily and now brush with it only once every couple days. My grin still sparkles. It is important to use a dry toothbrush and brush thoroughly in gentle circles for a full two minutes, even though you might drool a little while doing this. The results are gradual, but ultimately pleasing and far less expensive than most other approaches to tooth whitening. I highly recommend this product to you.

  • Lauren Richards - Good for... well, it's just good

    I have a miniature Daschund named Sophie who is rather feisty, trying to brush her teeth simply ended with both of us angry at each other. She's just a year old, but I could already see plaque build up on her teeth. I asked the groomers at petco and they suggested this product, even showing me before and after pictures of their own pets. It's been (lets see thurs, fri, sat, sun, mon) 5 days and there is already an improvement. I take up her water 30 minutes before and use about the same size (if maybe a bit smaller) that I would use on my own toothbrush. so about 1/2 teaspoon. She licks her lips when I grab the bottle. You don't need to be horribly thurough, I quickly rub it on her teeth inside and out and stop. She licks her chops for a moments and I put down her water (+ water additive) and she's doing great! I highly suggest this product if you and your dog are thinking about getting a divorce over teeth issues.

  • Amazon Customer - DE seems to work for me

    I've been taking 2 heaping tablespoons a day for 2 months, 1 in the AM and 1 in the PM. The immediate effect I noticed was a reduction in acid reflux which I experienced on a regular basis. I was taking Zantac to combat this which was very effective in my case but since using DE I have not had to do this. I also experienced itchy skin, especially at night after I went to bed, mostly my lower legs, ankles and feet and it drove me crazy. I tried various lotions and Aveno Eczema lotion worked the best. Now within the last few weeks the itching has almost gone away and I have not had to use any lotion at all. I am beginning to become a believer in the stuff. For the indigestion it was almost immediate. For the itchy skin it took about 6 weeks. So give it time.

  • Sam Gotsis - Pretty good

    The video comes out fine. I like it quite a bit. The internal mic isn't the best, hence 4 stars. I've used camcorders with really good built in mics, and not having to voice over your videos is a big thing, depending on what you're filming. I make TWD scene re-enactments, and I have to voice over most of it. But the picture is good. Mic is alright. Good camcorder. Easy to use.