La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Becky Bertuzzi - Great Antenna Replacement!

    I purchased this for a 2012 Chevy Equinox (the existing antenna was too long for my garage door). It was very easy to install and I don't notice a difference in sound quality. The price is extremely reasonable and it was the perfect solution for my door height on the garage door.

  • Jazzykins90 - Slow at times, but moved faster towards the end

    I do feel in a way this book could've ended 100 pages ago. It was kind of suspenseful...not one of the best that I've read. Certain parts seemed to drag on unnecessarily and I found myself saying throughout the book, just where is the child and give her back so we can move on. But I did like this ending surprisingly...but midway through I did figure out what was going on and it wasn't the obvious so I guess that's a good thing. Overall, not a "must-read" but this can be a definite quick, easy read.