La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Barb C - I love Flexitol Heel Balm

    I love Flexitol Heel Balm. It is the best product I've found in my 60 years of trying different heel products. In the winter, if I don't use it, my heels will crack/ split open. Those splits are very painful when walking. Flexitol Heel Balm will soften the tough calloused skin and heal up the split quickly. I also use it on my fingers. I am a nurse and wash my hands A LOT! I'll often develop a split on my finger tip hear at the side of the nail. I apply the Flexitol to my hands and the split on my finger at night and when I can durning the day. It helps heal the split on my finger tips and helps my hands recover from so much hand washing.

  • Lisa Wright - Stopped working!

    My Fitbit Flex worked for a little over a month. Then it stopped working, showing dots like this: ** **. A couple of weeks later, it flashed a few times and started working again. The next time I had to charge it (about 7 days after it started working again), it went blank and now no amount of tapping will bring it back to life. By now I'm out of the 45-day refund policy, so I wish I'd jumped when it first stopped working.