La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    We used this bedframe (the version from 7yrs ago) from then until now with no problems whatsoever. The only reason we're not using it now is because we graduated to a king (more kids on the way). We are selling the queen, and it is still in excellent condition. I'd say we were about a 400lb total weight on this bed most nights. It was fairly easy to assemble, as well as disassemble (although my husband and I are both handy and enjoy putting together Ikea furniture). Not sure why so many others marked it with so few stars...

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