La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Ashley Exparza - Cracks you out

    Don't use this! It makes you super cracked out! I can drink several cups of coffee without feeling jittery and this stuff was like speed!

  • Marcia Hayes - Gummy

    I love this game, 10 points you get for each level is ridiculous. 30 1st young then 60 & 90 would be more like it. Too bad you can't carry points from one country to another. Why only 3 or 5 lives ,some levels may take more lives than that to get thru.

  • Kelly - Runs small

    It runs a little small but glad we had that in mind and ordered a medium for my 10yr old sister. She looks up to this soccer player. She was very Happy with it and couldn't wait to wear it.

  • Karen - Pretty damn good

    Great way to get some fun cardio into the day! Only downside is that would love to have more free songs! But yeah... in a perfect world I guess :P