La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • TedandAmy - Binding were set to specified length

    I purchased these same skies from this same vendor... Through their website directly (not amazon) as they were running a 10% off sale at the time. Not only were the bindings attached, they set them to the specified length of my ski boot! Additionally, both by phone and email, they were helpful and responsive to my questions about proper length of ski to purchase for my height, current weight, and experience. To be safe, it is recommended that you should always have new bindings tested at a shop for release and proper setting of Din number. That said, I would highly recommend this vendor! Can't comment on the skis them-self, as I haven't used them yet. They certainly are ascetically beautiful skis. Will update review after use.

  • Rebecca Yalch - Really elementary

    Could have been good if rose above 4th grade reading level. Ending totally flat. Was this supposed to be a fable with a moral

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