La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Victoria J. Mejia-Gewe - Impress your friends with your knowledge of many fascinating facts and stories!

    I've been subscribed to Dan Lewis's daily emails of fascinating facts for about a year, so I was very excited to see he was releasing a book. This is a great book for those times when you don't want to get deep into reading something long and involved, as each chapter stands alone and is just two or three pages short.

  • nihongasuki - It's good but not great

    I bought this mainly for my bikini area. I live by the ocean and love to surf. I am allergic to wax and shaving caused red bumps and ingrown hairs like you wouldn't believe. I bought this mainly to solve that issue and because I liked the idea of going long periods of time without having to shave or do anything. It works sort of. I have treatment areas that really took care of the hair and then some where hair seemed to not be affected at all. I have light olive skin (no tan at the moment) and extremely dark hair, which should be perfect. So far, I am still having to shave but with no red bumps or ingrown hairs. I treat every two weeks as well. Hopefully it will start working better. I may have to set it higher. I currently run it on three, which is the middle. I guess the real take away is what you initially purchased the machine for. I did buy this with the hopes of getting rid of the red bump and ingrown hair problem. But I also wanted to shave less and not have to worry about whether or not I needed to shave before getting in my suit. Overall, I do like it though.