La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Advanced Interventions Service - Home - Dundee Advanced Interventions Service. Specialist assessment and treatment of chronic, treatment-refractory depression and obsessive-compulsive disorder (OCD).

  • http://www.advancedinterventions.org.uk/index.php/the-service/referral-information/patients.html Advanced Interventions Service - I am a Patient/Carer - Information for patients and carers on how to be referred to the service. Also provides details on what to expect.
  • http://www.advancedinterventions.org.uk/index.php/the-service/assessment-process.html Advanced Interventions Service - Assessment Process - Details about the assessment process in Dundee - explains what to expect if you or a relative is being seen by the service.
  • http://www.advancedinterventions.org.uk/index.php/the-service/contact-us.html Advanced Interventions Service - Contact Us - Contact Details for the service, including mailing address, telephone, fax, and email addresses.
  • http://www.advancedinterventions.org.uk/index.php/the-service/how-to-find-us.html Advanced Interventions Service - How to Find Us - Information on the location of the service and details on how to reach us by car, train, or plane.
  • http://www.advancedinterventions.org.uk/index.php/interventions/history-of-nmd.html Advanced Interventions Service - History of NMD - A history of Neurosurgery for Mental Disorder from Phineas Gage, through Freeman & Watts, to the present day.
  • http://www.advancedinterventions.org.uk/index.php/ocd/ocd-treatment-guidelines.html Advanced Interventions Service - OCD Treatment Guidelines - Current treatment guidelines for treatment-refractory OCD. Explains the steps expected to have been tried before neurosurgical treatment.

    Country: 217.160.231.243, Europe, DE

    City: 9.491 , Germany

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