La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.
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I got the Sitar within a week and it was packed very nicely. It plays well, however, there was no extra set of strings or mizraabs as promised in the product description. Also, it would have been nice if there was some information about the best speakers for it. We only got a booklet that explains how to play a sitar.
After reading a whole bunch of reviews and comparing all the different gel nail options, I was pleasantly surprised at the ease of use and great results of this kit. I watched the instructions video on the sensationail website a few times. I also read a bunch of websites with tips for gel nail application in general (e.g. don't apply after your nails have been soaking in water, make sure to wipe off any product that gets on your skin, make sure that the coats are very thin). I half expected the manicure to fall off quickly the first time I tried it. That seems to be the experience of some people. However, mine didn't. It was starting to chip a little after one week and so I removed it by peeling it off. (Note that I was able to do that without soaking in acetone). I attribute the chipping to beginner's error in applying the product. I made some mistakes in the first application, which is why I was particularly astounded by the overall very good results.