La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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  • Austin D. - Great for just over half a year...

    Worked great while it lasted, but died after 7 short months. For the price, it was awesome because it has a Gigabit WAN port, able to do PAT for some services behind my router, setup private and guest wireless, and setup a SMB share using a 3TB external HDD hooked directly up to the router. However, the router will only stay online for approximately 90 seconds now before rebooting in an endless cycle. The lifespan on this particular one was unexpectedly low and unsatisfying. Reaching out to ASUS for a warranty replacement, but will most likely be looking for a new router this weekend...

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