La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

BioCryst: Home - BioCryst Pharmaceuticals designs, optimizes and develops novel small-molecule drugs that block key enzymes to treat rare diseases.

  • http://www.biocryst.com/about_biocryst BioCryst: About BioCryst - With expertise in drug discovery, clinical development and regulatory affairs, BioCryst Pharmaceuticals continues to advance its clinical programs and to generate new compounds from its own discovery engine.
  • http://www.biocryst.com/company_overview_mission BioCryst: Company Overview - BioCryst Pharmaceuticals designs, optimizes and develops novel small-molecule drugs that block key enzymes involved in infectious and inflammatory diseases.
  • http://www.biocryst.com/management_team BioCryst: Leadership Team - Jon P. Stonehouse, a pharmaceutical executive for more than 20 years, has strong commercialization, financial transaction, business development and management expertise.
  • http://www.biocryst.com/careers BioCryst: Careers - BioCryst's greatest asset is its highly experienced and committed team of employees; together, we are working to design, optimize and develop novel small-molecule pharmaceuticals that block key enzymes involved in infectious diseases, cancer and inflammatory diseases.
  • http://www.biocryst.com/clinical_pipeline BioCryst: Pipeline & Product - BioCryst Pharmaceuticals designs, optimizes and develops novel small molecule drugs that block key enzymes involved in infectious and orphan diseases, with the goal of addressing unmet medical needs of patients and physicians.
  • http://www.biocryst.com/news BioCryst Pharmaceuticals Inc. - Press Releases - BioCryst Pharmaceuticals designs, optimizes and develops novel small-molecule pharmaceuticals that block key enzymes involved in infectious diseases, inflammatory diseases and cancer.

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  • Mackey Stingray - Works well for older iDevices

    Works well in a CTS-V1 (04-07) and plug n play to your existing harness. Programmable buttons so you can pick artist, random, playlists, etc from the head unit, not have to use your phone though you can still do that.

  • DeuceDawg287 - No blockbuster, but entertaining!

    My daughter's friends were all a buzz over this movie so I rented it so she could see what the hype was. I had seen it before, but it was fun to watch it with her. Definitely not Oscar material by any means, but somewhat entertaining, from a "yikes, what the heck would you do if something crazy like that happened?!?!"

  • Semolina - Came fully inflated and works like the usual volleyball

    Makes me smile whenever I see it. Came fully inflated and works like the usual volleyball. Of course, my kids don't "get" it.

  • D. Graves - Why does this now have over 4 THOUSAND negative reviews?

    The Flex is fairly good - IF you understand its limitations. And it has a lot of them. This is a 1.0 version, the first wrist-based tracker Fitbit has produced. There are good reasons why there are so many negative reviews of the Flex. I strongly suggest that you wait for the technology to be refined by Fitbit (and others) before spending $100 or more on this.