La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

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    Country: 80.157.150.17, Europe, DE

    City: 9.491 , Germany

  • Eleah - so fun!

    Tried this game at Christmas at a friends house. Really liked it so decided to buy. . Just before new years I ordered, then rented from redbox so I could take my wii, and this game to my sisters house to play with offers at her party. .SO MUCH FUN! WAY better than DDR.

  • Brian Thomas - Does it matter?

    Enjoyable, a quick read, occasionally amusing. The thing is, no one will have their minds changed by this. It would be interesting to see what the enthusiastic swallowers of the bogus Obama "exposes " think of this, but I doubt that it would amount to caustic, angry, sad and perhaps perverse entertainment for the left. In sum, while diverting, this is just another vignette of how great and rancorous the present political divide is in this country.