La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Cato Research - International Contract Research Organization | Research Triangle Park, Durham, North Carolina - Cato Research is a full-service contract research and development organization (CRO) with international resources dedicated to helping pharmaceutical and biotechnology companies efficiently and expeditiously navigate the regulatory approval process in order to bring new drugs, biologics, and medical devices to the people who need them.

  • http://www.cato.com/cato-strategic-locations.shtml Cato Strategic Locations | Cato Research Communications Registry | Cato Research - Contract Research Organization | Research Triangle Park, Durham, North Carolina - Cato Research offers international drug development capabilities through its office locations in the United States, Canada, Europe, South Africa, Israel, India.
  • http://www.cato.com/cato-research-careers.shtml Cato Careers in Drug Development and Drug Research | Cato Research Communications Registry | Cato Research - Contract Research Organization | Research Triangle Park, Durham, North Carolina - As an international contract research organization, Cato Research is an expanding company with many opportunities for professional growth and advancement in the life science industry.
  • http://www.cato.com/contact-cato-research.shtml Contact Us | Locations | Cato Research Communications Sign Up | Research Triangle Park, Durham, North Carolina - Cato Research is an international contract research organization that is headquartered in the Research Triangle Park of Durham, NC, United States.
  • http://www.cato.com/cato-research-canada_french.shtml À Propos de Cato Recherche | Cato Recherche Canada | Saint Laurent, Montreal, Quebec Canada - Cato Recherche Canada est une compagnie privée offrant aux entreprises pharmaceutiques, de biotechnologie et d'instruments médicaux, des services de recherche contractuelle de haute qualité, couvrant toutes les phases de développement.
  • http://www.cato.com/services.shtml Services | Clinical Trials, Regulatory Affairs, Preclinical, Project Management | Drug Development - Cato Research offers a full range of services covering every phase of the drug development process including: Clinical Operations, Clinical Trials, Clinical Strategy, Regulatory Strategy, Regulatory Affairs, IND, Data Management, Biostatistics, Medical, PK, Preclinical, Project Management, Quality Assurance, NDA and more.
  • http://www.cato.com/experience.shtml Experience | Drug Development | Regulatory and Clinical | Cato Research - Contract Research Organization (CRO) - Cato Research has over 25 years of drug research and development experience, including extensive regulatory and clinical knowledge and frequent FDA regulatory interactions.

    Country: 206.188.193.60, North America, US

    City: -81.5401 Florida, United States

  • ladybug - great

    i love the updated, information. I am a hair dresser and it's imperative I keep up on accurate learning. This book is a excellent tool. I refer to it often. thank you

  • Amazon Michelle - one hot calabration

    I loved this book it was so hot and steamy very tempting would love to have a bad boy like this in my house yeah I would love it so much Liam is a bad boy but he fell in love with Elle the first time he meets her Elle is in college and just had her dad now he has died and she is coming home to take care of things but finds out he owes money to the bad guys and did not know anything about it and Liam and Elle are running together from the evil that has found them. This was a awesome read loved every minute of it could not put this book down. I voluntarily reviewed and advanced reader copy of the book and it was so hot and steamy too wow. Michelle 

  • Gayle - Webroot - The Best

    I have been with Webroot since I purchased my first laptop over 10 years ago. I have never had a problem with anything. Even when a major virus tried to come through, it stopped it immediately. I took my computer to a place to check my laptop, and they said it was a Trojan that tried to come through but Webroot caught it and cleaned it out fast. I never know when the software is running as it runs fast and smooth.

  • William J. Powell - Access 2010: The Missing Manual

    Great book, I like it. I have used several ACCESS books from different authors/publishers. O'Reilly had a good reputation and it was correct. I wouldn't hesitate to buy other O'Reilly books. Also got the digital version.