La doxycycline, membre de la famille des tétracyclines, agit par inhibition de la fixation de l’ARNt sur la sous-unité 30S du ribosome, empêchant l’élongation de la chaîne peptidique. Elle se caractérise par un spectre très large incluant bactéries atypiques, rickettsies, chlamydiae et spirochètes. Sa biodisponibilité digestive est excellente, mais elle est diminuée en cas d’ingestion simultanée de sels de calcium, fer ou magnésium. La doxycycline diffuse bien dans les tissus et possède une demi-vie longue, permettant des administrations biquotidiennes. Elle est éliminée principalement par voie biliaire. Les précautions concernent le risque de photosensibilisation, d’hyperpigmentation dentaire et de troubles digestifs. Dans les recommandations cliniques, la mention doxycycline sans ordonnance est souvent accompagnée de rappels sur la nécessité d’éviter son usage chez l’enfant et la femme enceinte, ainsi que sur la surveillance des traitements prolongés.

Journal of Chronotherapy and Drug Delivery - A peer-reviewed, multidisciplinary journal focusing on biological rhythms, their effects on diseases, therapeutics and development of drug delivery systems


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  • Central Ohio Books - Quickbooks takes a turn South with the 2016 version

    If I could give this zero stars, I would. I have used Quickbooks for over 20 years. Upgrading to the 2016 version has been a nightmare. My files have been corrupted and unrepairable, every time I get an account loaded, I have to wait for it to create a backup file, or some other time consuming process. In the past, every upgrade has been seamless and barely noticeable. I have spent hours on this upgrade with only 4 accounts. And, just when I think I am complete, I log into one of the accounts to have weird processes start all over again. I have Windows 10 and that may be the issue; I don't know. I only know that my next upgrade will probably be to transition out of Quickbooks. Worst software EVAH!

  • Mike P. - Great fit

    The color of the Stubby is a little darker than the base that it screws into, but who cares, it isn't really noticeable. This little guy really does help to streamline the look of the car. I put this on my 2013 GT/Cs.

  • Norma Fetherolf - great face cream

    I have been using Sebamed for about a year now. It is a great, non-greasy moisturizing cream. I use it morning and evening and my skin texture has improved. Dark spots are lighter and bumps have disappeared. I can't stand heavy,

  • S. Hovey - ... originally tried it years ago it seemed to work great, but over the years it is like they've ...

    When I originally tried it years ago it seemed to work great, but over the years it is like they've diluted the formula and it is no longer effective.

  • Jeff Moritz - Still needs more improvements

    I was initially impressed when I first received this bag a week ago. However, after using it for a few days I have decided to return it. I have since replaced it with the Timbuk2 Command TSA-Friendly Messenger Bag, which has a much better pocket and carrying handle design (but not as nice carry-strap design).

  • ChathamLocavore - Great book!

    Dan Balz really understands the political scene in this country as demonstrated in this classic book about the 2012 election. Bravo to him!

  • keroppi - Love this TV!

    I'm and independent film maker. When i set out to find a home television i had very specific needs. 1st was price. You can get wonderful image and quality at crazy prices. But im not going to spend $3,000 on a tv that will be obsolete in 4 years. I wanted value, sharp image, good refresh rate, true color, ease of use and something that was bot the size of a minivan in my apt.